The thin-wall beam that has a major impact on the safety of the body was optimized, the design of the thin-walled beam was proposed,which was necessary to consider safety, static load-bearing characteristics and the first order vibration mode. At the same time, the process of optimizing design involved material, size, layout of the spotwelds, and many other parameters, the traditional deterministic optimal design results often converged to the subjecting border, and could not meet the reliability requirements of product design.Combined with design of experiment, response surface models, reliability theory and genetic algorithms, the reliability of multidisciplinary design optimization method of thin-walled beam was constructed based on the product quality engineering.Comparing with the traditional deterministic optimization results, we know that reliability optimization results meet better the established lightweight objectives, and make thin-walled beam reliability a notable increase.