Under conditions of mass customization collaborative manufacturing chain for optimized configuration,taking quality,cost,time ,delivery lead time and collaboration degree as evaluation index system,and aggregative value minimum of evaluuation indices as object,an optical model of mass customization collaborative manufactuing chain was established. Based on genetic algorithm and ant colony algoithm, an improved mixed genetic-ant colony algorithm was constructed,which was suitable to the proposed problem,and the solution process was explained. At last ,an example and comparation were presented to prove the feasibility and validity of the proposed algorithm.The method provides reference model and solution algorithm for mass customization collaboration manufactuing chain optimization.