Based on AAR, BS, IIW, ASME and other standards for fatigue analysis,a railway wagon welded structure fatigue life prediction special software was studied. The software was planned as seven core modules, such as Verity method, structural stress reverse method etc., and the collaborative network database systems and common standards support systems were constituted key elements of the software systems. Software based on nested mesh-insensitive structural stress of technology, and mathematical model of the master S-N latest Verity method; formula for AAR standards of structural stress in reverse was derived,the mathematical expression of load strength and structural damage factors was defined;SQL-Server, Access database and ADO technology were used to achieve the network database support. Finally, four-axis welding clamp car bogies as an example were used to prove the validity and usefulness of the software system.