In order to improve the characteristics of a liquid hydrostatic slide, the influences of the viscosity of five different grades of hydraulic oil on the characteristics of the slide system were analyzed quantitatively. First, based on the practical working conditions, the initial design parameters of the hydrostatic slide system and the dynamic viscosities of different brands of hydraulic oil at different temperatures were calculated. Then based on force balance equation and flow equation of the hydrostatic slide, the linearized mathematical models of power loss, static performance and dynamic performance of the hydrostatic slide were established. Total power loss, bearing capacity, static stiffness, natural frequency, adjusting time, dynamic stiffness were regarded as the key performance indexes of the hydrostatic slide system. Finally, the influences of the hydraulic oil viscosity on the characteristics of ultra-precision hydrostatic slide system were simulated with MATLAB software. The results indicate that as the grade of hydraulic oil increases (VG22→VG100) and the working temperature decreases (60℃→10℃), the viscosity increases accordingly, and then the total power loss decreases from 507.58W (VG22, 60℃) to 33.93W (VG100, 10℃), the bearing capacity, the static stiffness and the natural frequency remain constant, the adjusting time decreases from 29.84μs (VG22, 60℃) to 0.46μs (VG100, 10℃), and the dynamic stiffness increases from 173kN/μm (VG22, 60℃) to 10 369kN/μm (VG100, 10℃). So it is best to increase the viscosity of hydraulic oil in order to decrease the power loss and to improve the dynamic characteristics of hydrostatic slide system, but the static characteristics are not affected.