The cylindrical grinding experiments by using different characteristics for the grinding wheel of the GH4169 superalloy were studied by the single factor experimental method. The influence of the single crystal corundum wheels and CBN wheels on surface roughness and surface topography in the grinding surface characteristics of GH4169 superalloy were researched, the influence regularity of grinding parameters on the surface roughness and chip shape was analysed, and the grinding surface topography was observed. The results show that, when cylindrical grinding GH4169 superalloy by using the single crystal corundum wheels, with particle size for 80, ZR1, the binders for ceramic, the surface characteristics is more stable, and the surface roughness is lower, the trajectory of grinding feed movement constitutes the main feature of the machined surface topography. However, with the workpiece speed ranging from 8m/min to 21.66m/min, the wheel speed from 15m/s to 30m/s, the radial feeds from 0.005mm to 0.02mm, the longitudinal feed from1.3~3.6mm/r to 3.6mm/r, the surface roughness can be controlled within the value of 0.14μm.