Micro-gripper as end devices, directly determined the efficiency of the micro-assembly. MEMS mechanism contained many tiny moving parts and functional elements, so as to achieve the stabally gripping and automatic assembly of these tiny devices. A micro-gripper with two grade displacement amplification was designed, which was actuated by piezoelectric ceramics and based on flexible hinges. The micro-gripper node stress, stiffness and maximum deformation, etc. were analyzed and calculated, and the micro-gripper prototype was produced. The experimental results show that the maximum deformation levels of the gripper is as 245μm, the magnification is about 12.3 times, that meets the requirements of MEMS micro-assembly. On this basis of above, the deformation and gripping force were focused on, and a formula of 99.99% reliability drive voltage was derived by nonlinear regression of the test data, and the precise control of the micro-gripper is achieved.